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Synthetic marijuana compounds , sometimes call K2 or Spice , are in reality chemically different from marijuana , and are more dangerous than pot , according to a new review of work .
Synthetic marijuana compoundsare relate to a figure of serious side effects , admit seizure , psychosis and even death , the recapitulation ’s authors said .
These compounds " bring on a variety of severe acute accent and inveterate adverse effects … with a greater rigour and oftenness than observed following marijuana use , " the research worker wrote in theirreview , which was published Feb. 2 in the journal Trends in Pharmacological Sciences . Therefore , " K2 / Spice products are clearly not safe marijuana option , " the researchers said . [ 6 Party drug That May Have Health benefit ]
manufacturing business first start to sell synthetic marijuana compounds in the early 2000s . The mathematical product are often market as " safe " alternatives to marijuana that will not show up on a stock drug test .
In the former 2000s , " we start seeing all variety of people coming into parking brake room saying they smoked marijuana , but then they had these really bizarre symptoms that did not correspond with the consequence you see with marijuana , " Paul Prather , a cellular and molecular pharmacologist at the University of Arkansas for Medical Sciences ( UAMS),said in a statement .
There are now more than 150 different type of synthetic marijuana compound , the researchers said . The products are design to aerate two receptor in the body , called CB1 and CB2 — the same receptors thattetrahydrocannabinol ( THC ) , the active ingredient in marijuana , binds to . But although they activate the same receptors , synthetic marijuana chemical compound are structurally different from marijuana , the researchers said . In addition , as a radical , these compounds have various chemical substance structures , meaning that they are often quite different from each other as well , they say .
Many type of man-made marijuana compounds are illegal in the United States , but hush-hush manufacturers continue to produce new compound that are n’t always covered by subsist laws and are n’t always detected by current drug tests , the researchers said . [ 9 eldritch Ways you may Test Positive for Drugs ]
Some of the reported side effects of semisynthetic marijuana compound include convulsions , kidney injury , toxicity to the marrow , chance event and anxiety . So far , 20 death have been connect to the use of semisynthetic marijuana compounds , the researchers read .
Studies have found that these compound tend to spark off the CB1 sensory receptor to a greater degree than does THC , suggesting that synthetic marijuana compounds have the ability to bring on far more intense effect than marijuana , according to the reappraisal .
In addition , when some of these compounds are broken down in the body , their by - products also have the power to activate the CB1 receptor , which could lend to the increase toxicity of the drug , they pronounce . What ’s more , because of their divers structures , synthetical marijuana compound may also spark off other sense organ besides CB1 and CB2 — which could explain why these drugs grow someadverse side gist that are not seen with marijuana , they said .
The researchers also note that when people purchase synthetic marijuana compounds , they do n’t make out what ’s really in the product that they are buy .
" Not only does the amount of the dynamic pharmacological agent alteration with different flock of drug , made by unlike labs , but the combat-ready compound itself can change , " said William Fantegrossi , a behavioural pharmacologist at UAMS . And there are ordinarily a minimum of three unlike types of synthetic cannabinoids in a single mathematical product , the researchers state .
More research is involve to determine exactly why synthetic marijuana compounds seem to be more toxic to people than marijuana , the authors of the revue said .
Original article onLive skill .
